Senior Director of DMPK/ADME (Biotechnology, Boston or Copenhagen)

Job summary

This position involves leading the Drug Metabolism and Pharmacokinetics (DMPK) capabilities across various modalities, focusing on strategic leadership and operational delivery of nonclinical DMPK activities within a biotechnology setting. The role emphasizes building DMPK capabilities at the Boston site while ensuring integration with Copenhagen operations, and driving automation and AI-enabled workflows.

Qualifications

• PhD in pharmaceutical sciences or a related field with significant industry experience.
• Extensive background in addressing DMPK challenges across multiple modalities.
• Proven leadership experience in building and mentoring high-performing scientific teams in matrix environments.
• Experience in regulatory-facing DMPK content, including IND/CTA support.
• Ability to set DMPK strategy aligned with project priorities while balancing scientific rigor and resource constraints.
• Familiarity with oligonucleotides and small molecules is advantageous; experience with lab automation and AI workflows is a plus.

Responsibilities

• Provide strategic oversight for DMPK/ADME strategy and execution across the portfolio.
• Build and mentor DMPK capabilities at the Boston site, ensuring alignment with Copenhagen standards.
• Oversee bioanalytical method development and sample analysis.
• Lead in vitro ADME activities, ensuring appropriate study design and documentation.
• Manage in vivo pharmacokinetics and metabolite identification, integrating findings into decision frameworks.
• Deliver high-quality nonclinical PK summaries and integrated DMPK data packages.
• Implement continuous improvement through automation and digital approaches in DMPK workflows.
• Collaborate with cross-functional project teams and ensure effective oversight of external partners and CROs.
• Contribute to regulatory strategy and ensure DMPK content is inspection-ready.

Skills

• Strong communication skills to translate complex DMPK data into actionable recommendations.
• Collaborative and science-driven leadership style.
• Ability to operate in a fast-paced, multi-modal pipeline environment.

Education

• PhD in pharmaceutical sciences or similar field.

Tools

• Experience with automation and AI-enabled workflows in laboratory settings.