PhD Researcher in Protein Engineering (Biotechnology, Remote)

Job summary

A PhD position is available for a 3-year research project focused on developing environment-responsive antibodies and nanobodies. The project aims to create proteins that can modulate their activity based on environmental conditions, with applications in targeted therapeutics and biosensing.

Qualifications

• A 2-year M.Sc. degree in a relevant life sciences field such as biotechnology, biochemistry, molecular biology, or protein science.
• Strong experimental skills in molecular biology and/or protein science.
• Excellent communication skills in English.
• Ability to work collaboratively in an interdisciplinary environment.
• Strong project management and record-keeping skills.

Responsibilities

• Conduct in vitro discovery and characterization of binding proteins targeting natural toxins.
• Develop and optimize phage and yeast display workflows for antibody/nanobody discovery.
• Analyze data using next-generation sequencing (NGS) and bioinformatics tools.
• Perform biophysical characterization of binding interactions using techniques like SPR and BLI.
• Evaluate toxin binding and modulation under varying environmental conditions.
• Integrate experimental data with computational modeling approaches.
• Contribute to scientific publications and identify potential industrial applications.

Skills

• Experience with phage or yeast display technologies, antibody engineering, protein expression, and purification.
• Familiarity with biophysical characterization techniques and immunoassays.
• Knowledge of next-generation sequencing and data analysis.
• Skills in molecular modeling, generative protein design, and scripting (e.g., Python) are beneficial.

Education

• Enrollment in a PhD program subject to academic approval.

Tools

• Techniques such as SPR, BLI, NGS, and bioinformatics tools will be utilized.