Postdoctoral Researcher in Cell Biology

Job summary

We are looking for a motivated Postdoctoral Researcher to engage in a collaborative project that explores the intersection of synthetic biology, metabolism, and active matter physics using engineered mammalian cell lines. The role involves leading experimental efforts to connect metabolic changes with multicellular dynamics through innovative techniques.

Qualifications

• PhD degree (or equivalent) in a relevant field.
• Hands-on experience with mammalian cell culture and genetic engineering.
• Expertise in fluorescence microscopy, including live imaging and light-sheet microscopy.
• Proven ability to work in an interdisciplinary environment.
• Excellent communication skills in English, capable of conveying complex ideas to diverse audiences.
• Experience mentoring students at various academic levels.

Responsibilities

• Optimize optogenetic gene circuits and live-cell metabolic sensors to monitor energy flow in mammalian cells.
• Conduct metabolic phenotyping using functional assays such as Seahorse XF analyzers and isotopic tracing.
• Prepare samples for omic data generation, including metabolomics and transcriptomics.
• Design and execute 2D multicellular assays to study collective behaviors like cell migration and pattern formation.
• Perform experiments to investigate how metabolic states affect cellular mechanosensing and responses to mechanical cues.
• Analyze and interpret complex datasets from live-cell microscopy and metabolic sensors.
• Provide mentorship to PhD, MSc, and BSc students involved in the project.

Tools

• Seahorse XF analyzers
• Live-cell microscopy equipment
• Metabolic sensors
• Computational modeling tools