Principal Scientist - In Vitro Biology & Pharmacology (Biotechnology, Onsite)

Job summary

The role involves leading research projects focused on peptide-based drug candidates for obesity and metabolic health. The Principal Scientist will be responsible for advancing biological understanding and translating this into actionable preclinical data.

Qualifications

• Ph.D. in Biochemistry, Pharmacology, In Vitro Biology, or a related field with a minimum of 8 years of post-Ph.D. experience.
• Strong background in metabolism and/or obesity biology.
• Experience in drug discovery and/or development projects.
• Extensive knowledge of in vitro/ex vivo biological models, including primary cells.
• Familiarity with G-protein coupled receptor (GPCR) pharmacology is advantageous.
• Experience collaborating with external vendors and contract research organizations (CROs) is a plus.

Responsibilities

• Lead one or more research projects from concept to preclinical validation.
• Develop testable preclinical hypotheses based on mechanism-of-action insights.
• Create in vitro biological models relevant to obesity pharmacology.
• Conduct in vitro disease-model studies to evaluate molecular candidates and assist in selecting lead compounds.
• Analyze complex data related to pharmacology and cell biology, providing insights to senior leadership and external partners.
• Ensure thorough study design and documentation to facilitate decision-making and transitions to in vivo studies.

Skills

• Strong collaborative and communication skills.
• Ability to stay updated with relevant scientific advancements.
• Motivated by making a significant impact on patient-relevant science.

Education

• Ph.D. in a relevant scientific discipline.

Tools

• Experience with cellular assays and data analysis tools relevant to pharmacology and biology.