Principal Scientist - In Vitro Biology & Pharmacology (Biotechnology, Onsite)

Job summary

The Principal Scientist in In Vitro Biology & Pharmacology will lead research initiatives focused on peptide-based drug candidates for obesity and metabolic health. This role involves developing biological models and translating scientific insights into actionable preclinical hypotheses to support drug development.

Qualifications

• Ph.D. in Biochemistry, Pharmacology, In Vitro Biology, or a related discipline with a minimum of 8 years of post-Ph.D. experience.
• Strong foundation in metabolism and obesity biology.
• Proven experience in drug discovery and development processes.
• Extensive knowledge of in vitro/ex vivo biological models, including primary cells and cell-based assays.
• Familiarity with G-protein coupled receptor (GPCR) pharmacology is a plus.
• Experience collaborating with external vendors and contract research organizations (CROs) is advantageous.

Responsibilities

• Lead one or more research projects from concept through preclinical validation.
• Convert mechanism-of-action insights into testable preclinical hypotheses and measurable success criteria.
• Create and refine in vitro biological models pertinent to obesity pharmacology.
• Conduct in vitro disease-model studies to evaluate molecular candidates and inform lead compound selection.
• Analyze complex data related to pharmacology and cell biology, providing recommendations to senior leadership and external stakeholders.
• Ensure thorough study design and documentation to facilitate efficient decision-making and transition to in vivo studies.

Skills

• Strong collaborative and communication skills.
• Ability to stay current with advancements in disease-relevant science.
• Proactive in driving scientific discussions and fostering teamwork.

Education

• Ph.D. in a relevant scientific field.

Tools

• Experience with cellular assays and data analysis tools relevant to pharmacology and biology.