Postdoctoral Researcher in Genetic Tool Development

Job summary

This position involves developing next-generation genetic tools aimed at therapies for neurological diseases within a research lab focused on precision medicine. The role includes designing synthetic promoter libraries and screening them in human iPSC-derived neural cell types, utilizing various molecular and cell biology techniques.

Qualifications

• PhD in biotechnology, biomedical engineering, molecular biology, stem cell biology, or a related field
• Strong motivation and ambition for research
• Ability to work independently and collaboratively in a team
• Excellent communication skills in English (written and spoken)
• Background in genetic tool development, including pooled library construction and high-throughput screening
• Hands-on experience with human iPSC culture and differentiation into neural cells
• Practical knowledge of cloning techniques and flow cytometry (FACS)
• Basic bioinformatics skills

Responsibilities

• Design and generate pooled promoter libraries
• Culture and differentiate human iPSCs into neural cell types
• Conduct and analyze high-throughput screens
• Evaluate promoter activity using FACS, next-generation sequencing (NGS), and barcode sequencing
• Optimize regulatory sequences
• Supervise B.Sc./M.Sc. students

Skills

• Experience in promoter design, cis-regulatory elements, enhancer biology, or transcriptional regulation (desirable)
• Familiarity with CRISPR-Cas technologies or other genome engineering methods (desirable)

Education

• A PhD degree (or equivalent) is required.

Tools

• Molecular cloning, lentivirus production, human iPSC culture and differentiation, high-throughput screening, FACS, next-generation sequencing, and computational analysis.